Drug interactions
Bortezomib + Dronedarone
Severity: Moderate
Bortezomib and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase bortezomib exposure, potentially worsening peripheral neuropathy, cytopenias and gastrointestinal toxicity. The effect from moderate CYP3A4 inhibition is modest.
What this interaction means in plain words
Bortezomib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4, one of the enzymes metabolizing bortezomib.
What to do
Monitor blood counts and for neuropathy, and reduce the bortezomib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Dronedarone?
MediHelp rates the interaction as moderate. Bortezomib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase bortezomib exposure, potentially worsening peripheral neuropathy, cytopenias and gastrointestinal toxicity. The effect from moderate CYP3A4 inhibition is modest.
How serious is the interaction between Bortezomib and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neuropathy, and reduce the bortezomib dose if toxicity develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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