Drug interactions
Bortezomib + Etravirine
Severity: Moderate
Bortezomib and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower bortezomib exposure, potentially reducing efficacy. Bortezomib is not an established CYP2C19 inhibitor, so an effect on etravirine is unlikely.
What this interaction means in plain words
Bortezomib and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4-mediated bortezomib metabolism by etravirine.
What to do
Monitor disease response. Consider an alternative antiretroviral if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Bortezomib with Etravirine?
MediHelp rates the interaction as moderate. Bortezomib and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower bortezomib exposure, potentially reducing efficacy. Bortezomib is not an established CYP2C19 inhibitor, so an effect on etravirine is unlikely.
How serious is the interaction between Bortezomib and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response. Consider an alternative antiretroviral if response is inadequate.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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