Drug interactions
Bortezomib + Fluvoxamine
Severity: Moderate
Bortezomib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is metabolized in part by CYP3A4, CYP2C19 and CYP1A2, and fluvoxamine inhibits CYP2C19 and CYP1A2 strongly and CYP3A4 weakly. Exposure to bortezomib may rise somewhat, raising the risk of neuropathy, cytopenias and gastrointestinal effects.
What this interaction means in plain words
Bortezomib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP2C19, CYP1A2 and weakly CYP3A4, reducing bortezomib metabolism.
What to do
Monitor for peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity, and reduce bortezomib dose per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bortezomib and Fluvoxamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Fluvoxamine?
MediHelp rates the interaction as moderate. Bortezomib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib is metabolized in part by CYP3A4, CYP2C19 and CYP1A2, and fluvoxamine inhibits CYP2C19 and CYP1A2 strongly and CYP3A4 weakly. Exposure to bortezomib may rise somewhat, raising the risk of neuropathy, cytopenias and gastrointestinal effects.
How serious is the interaction between Bortezomib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity, and reduce bortezomib dose per labeling if toxicity develops.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
