Drug interactions
Bortezomib + Fosaprepitant
Severity: Minor
Bortezomib and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, through aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose, so any rise in bortezomib exposure is likely small and short-lived. It is commonly used as antiemetic support in oncology.
What this interaction means in plain words
Bortezomib and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Weak, transient inhibition of CYP3A4-mediated bortezomib metabolism.
What to do
No dose adjustment is needed. Monitor for bortezomib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Bortezomib with Fosaprepitant?
MediHelp rates the interaction as minor. Bortezomib and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, through aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose, so any rise in bortezomib exposure is likely small and short-lived. It is commonly used as antiemetic support in oncology.
How serious is the interaction between Bortezomib and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for bortezomib adverse effects as usual.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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