Drug interactions
Bortezomib + Itraconazole
Severity: Moderate
Bortezomib and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can modestly increase bortezomib exposure. This may heighten peripheral neuropathy, myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, which contributes to bortezomib metabolism.
What to do
Monitor blood counts and for neuropathy and gastrointestinal toxicity. Reduce the bortezomib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Itraconazole?
MediHelp rates the interaction as moderate. Bortezomib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can modestly increase bortezomib exposure. This may heighten peripheral neuropathy, myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neuropathy and gastrointestinal toxicity. Reduce the bortezomib dose if toxicity develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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