Drug interactions
Bortezomib + Mefloquine
Severity: Moderate
Bortezomib and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation, and bortezomib patients often have additional risks such as electrolyte shifts and vomiting. Combined use may raise the chance of ventricular arrhythmia.
What this interaction means in plain words
Bortezomib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive QT prolongation; bortezomib's effect is weakly established.
What to do
Use an alternative antimalarial if feasible. If both are needed, monitor the ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Mefloquine?
MediHelp rates the interaction as moderate. Bortezomib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation, and bortezomib patients often have additional risks such as electrolyte shifts and vomiting. Combined use may raise the chance of ventricular arrhythmia.
How serious is the interaction between Bortezomib and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antimalarial if feasible. If both are needed, monitor the ECG and keep potassium and magnesium within normal range.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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