Drug interactions
Bortezomib + Midazolam
Severity: Minor
Bortezomib and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is metabolised by CYP3A4 and is not a clinically significant inhibitor of it, so a pharmacokinetic effect on midazolam is unlikely. Patients on chemotherapy may still be more sensitive to sedatives.
What this interaction means in plain words
Bortezomib and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; bortezomib is a CYP3A4 substrate rather than an inhibitor.
What to do
Use standard midazolam dosing and monitor sedation in debilitated patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Midazolam?
MediHelp rates the interaction as minor. Bortezomib and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is metabolised by CYP3A4 and is not a clinically significant inhibitor of it, so a pharmacokinetic effect on midazolam is unlikely. Patients on chemotherapy may still be more sensitive to sedatives.
How serious is the interaction between Bortezomib and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard midazolam dosing and monitor sedation in debilitated patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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