Drug interactions
Bortezomib + Omeprazole
Severity: Minor
Bortezomib and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib has shown only weak inhibition of CYP2C19 in vitro, and an increase in omeprazole exposure is not expected to be meaningful. A pharmacokinetic study showed a modest change at most.
What this interaction means in plain words
Bortezomib and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition by bortezomib may slightly raise omeprazole levels.
What to do
No dose adjustment is required; no specific monitoring beyond routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Omeprazole?
MediHelp rates the interaction as minor. Bortezomib and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib has shown only weak inhibition of CYP2C19 in vitro, and an increase in omeprazole exposure is not expected to be meaningful. A pharmacokinetic study showed a modest change at most.
How serious is the interaction between Bortezomib and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; no specific monitoring beyond routine care.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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