Drug interactions
Bortezomib + Ribociclib
Severity: Moderate
Bortezomib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise bortezomib exposure, since bortezomib is partly metabolized by CYP3A4. This may increase bortezomib toxicities such as neuropathy, thrombocytopenia and gastrointestinal effects.
What this interaction means in plain words
Bortezomib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolism of bortezomib.
What to do
Monitor for bortezomib toxicity, particularly peripheral neuropathy and platelet counts, and reduce the bortezomib dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Bortezomib with Ribociclib?
MediHelp rates the interaction as moderate. Bortezomib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise bortezomib exposure, since bortezomib is partly metabolized by CYP3A4. This may increase bortezomib toxicities such as neuropathy, thrombocytopenia and gastrointestinal effects.
How serious is the interaction between Bortezomib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib toxicity, particularly peripheral neuropathy and platelet counts, and reduce the bortezomib dose if adverse effects appear.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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