Drug interactions
Bortezomib + Selinexor
Severity: Moderate
Bortezomib and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor is used with bortezomib and dexamethasone in myeloma, so this is an approved regimen. The combination can cause additive thrombocytopenia, gastrointestinal effects, fatigue and neuropathy. It is not a contraindicated interaction.
What this interaction means in plain words
Bortezomib and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Selinexor belongs to Oncology.
Why it happens
Additive pharmacodynamic toxicity; no pharmacokinetic mechanism is established.
What to do
Use per approved regimen with dose modifications, monitoring platelet counts, neuropathy and nausea. Provide antiemetic prophylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Bortezomib with Selinexor?
MediHelp rates the interaction as moderate. Bortezomib and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor is used with bortezomib and dexamethasone in myeloma, so this is an approved regimen. The combination can cause additive thrombocytopenia, gastrointestinal effects, fatigue and neuropathy. It is not a contraindicated interaction.
How serious is the interaction between Bortezomib and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use per approved regimen with dose modifications, monitoring platelet counts, neuropathy and nausea. Provide antiemetic prophylaxis.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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