Drug interactions
Bosentan + Crofelemer
Severity: Minor
Bosentan and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit intestinal CYP3A4 but is minimally absorbed, so systemic effects on bosentan are unlikely. A small rise in bosentan exposure is theoretically possible.
What this interaction means in plain words
Bosentan and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of gut-wall CYP3A4 by crofelemer may slightly reduce bosentan first-pass metabolism.
What to do
No dose change is needed; continue routine monitoring of liver function and bosentan tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Bosentan with Crofelemer?
MediHelp rates the interaction as minor. Bosentan and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit intestinal CYP3A4 but is minimally absorbed, so systemic effects on bosentan are unlikely. A small rise in bosentan exposure is theoretically possible.
How serious is the interaction between Bosentan and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; continue routine monitoring of liver function and bosentan tolerability.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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