Drug interactions
Bosentan + Dihydroergotamine
Severity: Minor
Bosentan and Dihydroergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce dihydroergotamine concentrations by inducing CYP3A4, potentially lessening migraine relief. The clinical effect is generally a loss of efficacy rather than toxicity.
What this interaction means in plain words
Bosentan and Dihydroergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing dihydroergotamine clearance.
What to do
Monitor migraine response and consider alternative acute therapy if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Bosentan with Dihydroergotamine?
MediHelp rates the interaction as minor. Bosentan and Dihydroergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan may reduce dihydroergotamine concentrations by inducing CYP3A4, potentially lessening migraine relief. The clinical effect is generally a loss of efficacy rather than toxicity.
How serious is the interaction between Bosentan and Dihydroergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor migraine response and consider alternative acute therapy if efficacy is inadequate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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