Drug interactions
Bosentan + Eletriptan
Severity: Minor
Bosentan and Eletriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower eletriptan concentrations, since eletriptan is extensively metabolized by CYP3A4. Reduced triptan exposure may lead to less effective migraine relief.
What this interaction means in plain words
Bosentan and Eletriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by bosentan increases the metabolism of eletriptan.
What to do
Monitor for reduced headache response; a repeat dose within label limits or an alternative triptan can be considered if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Eletriptan?
MediHelp rates the interaction as minor. Bosentan and Eletriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate CYP3A4 inducer and may lower eletriptan concentrations, since eletriptan is extensively metabolized by CYP3A4. Reduced triptan exposure may lead to less effective migraine relief.
How serious is the interaction between Bosentan and Eletriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced headache response; a repeat dose within label limits or an alternative triptan can be considered if efficacy is lost.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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