Drug interactions
Bosentan + Estradiol
Severity: Moderate
Bosentan and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower estradiol concentrations. This may reduce efficacy of hormone therapy or hormonal contraception.
What this interaction means in plain words
Bosentan and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Estradiol belongs to Endocrine.
Why it happens
Bosentan induces CYP3A4, increasing estradiol metabolism.
What to do
Use a non-hormonal or additional barrier contraceptive method. Monitor menopausal symptom control and adjust estradiol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Estradiol?
MediHelp rates the interaction as moderate. Bosentan and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower estradiol concentrations. This may reduce efficacy of hormone therapy or hormonal contraception.
How serious is the interaction between Bosentan and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal or additional barrier contraceptive method. Monitor menopausal symptom control and adjust estradiol dose if needed.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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