Drug interactions
Bosentan + Fedratinib
Severity: Moderate
Bosentan and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower fedratinib concentrations, potentially reducing efficacy in myelofibrosis. The effect of inducers on fedratinib has not been well characterized, so the size of the effect is uncertain.
What this interaction means in plain words
Bosentan and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Fedratinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, which is a major metabolic pathway for fedratinib, and may reduce its exposure.
What to do
Monitor spleen response and symptoms and consider an alternative to bosentan where possible. Avoid adding further strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Bosentan with Fedratinib?
MediHelp rates the interaction as moderate. Bosentan and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower fedratinib concentrations, potentially reducing efficacy in myelofibrosis. The effect of inducers on fedratinib has not been well characterized, so the size of the effect is uncertain.
How serious is the interaction between Bosentan and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen response and symptoms and consider an alternative to bosentan where possible. Avoid adding further strong inducers.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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