Drug interactions
Bosentan + Finerenone
Severity: Moderate
Bosentan and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan, a moderate CYP3A4 inducer, may reduce finerenone exposure and weaken its renal and cardiovascular protective effect. The reduction is expected to be less than with strong inducers.
What this interaction means in plain words
Bosentan and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Finerenone belongs to Cardiovascular.
Why it happens
Bosentan induces CYP3A4, the main enzyme metabolizing finerenone.
What to do
Monitor serum potassium and renal function, and watch for reduced efficacy. Avoid strong inducers and consider alternatives if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Bosentan with Finerenone?
MediHelp rates the interaction as moderate. Bosentan and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan, a moderate CYP3A4 inducer, may reduce finerenone exposure and weaken its renal and cardiovascular protective effect. The reduction is expected to be less than with strong inducers.
How serious is the interaction between Bosentan and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, and watch for reduced efficacy. Avoid strong inducers and consider alternatives if response is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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