Drug interactions
Bosentan + Ixazomib
Severity: Moderate
Bosentan and Ixazomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer, and it could lower ixazomib exposure and reduce its efficacy. Strong inducers markedly reduce ixazomib exposure, while the effect of moderate inducers is expected to be smaller.
What this interaction means in plain words
Bosentan and Ixazomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Ixazomib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4 and increases ixazomib metabolic clearance.
What to do
Consider an alternative to bosentan if possible, and monitor the myeloma response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ixazomib?
MediHelp rates the interaction as moderate. Bosentan and Ixazomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer, and it could lower ixazomib exposure and reduce its efficacy. Strong inducers markedly reduce ixazomib exposure, while the effect of moderate inducers is expected to be smaller.
How serious is the interaction between Bosentan and Ixazomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to bosentan if possible, and monitor the myeloma response.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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