Drug interactions
Bosentan + Levamlodipine
Severity: Minor
Bosentan and Levamlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower levamlodipine concentrations through CYP3A4 induction. Blood pressure control may be reduced, although bosentan itself lowers blood pressure.
What this interaction means in plain words
Bosentan and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Levamlodipine belongs to Cardiovascular.
Why it happens
Bosentan induces CYP3A4, increasing metabolism of levamlodipine.
What to do
Monitor blood pressure and adjust levamlodipine dosing as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Bosentan with Levamlodipine?
MediHelp rates the interaction as minor. Bosentan and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan may lower levamlodipine concentrations through CYP3A4 induction. Blood pressure control may be reduced, although bosentan itself lowers blood pressure.
How serious is the interaction between Bosentan and Levamlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust levamlodipine dosing as needed.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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