Drug interactions
Bosentan + Oxycodone
Severity: Moderate
Bosentan and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4, the main pathway for oxycodone metabolism, which may lower oxycodone concentrations and reduce analgesia. Conversely, stopping bosentan could raise levels again.
What this interaction means in plain words
Bosentan and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Oxycodone belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by bosentan increases oxycodone clearance.
What to do
Monitor pain control and adjust the oxycodone dose upward if needed. Re-evaluate for opioid toxicity if bosentan is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Oxycodone?
MediHelp rates the interaction as moderate. Bosentan and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4, the main pathway for oxycodone metabolism, which may lower oxycodone concentrations and reduce analgesia. Conversely, stopping bosentan could raise levels again.
How serious is the interaction between Bosentan and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and adjust the oxycodone dose upward if needed. Re-evaluate for opioid toxicity if bosentan is discontinued.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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