Drug interactions
Bosentan + Palbociclib
Severity: Moderate
Bosentan and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may reduce palbociclib exposure. This could lower antitumor efficacy.
What this interaction means in plain words
Bosentan and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Palbociclib belongs to Oncology.
Why it happens
Induction of CYP3A4-mediated palbociclib metabolism by bosentan.
What to do
Monitor tumor response; consider an alternative to bosentan where feasible. Avoid strong inducers, and moderate inducers need closer attention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Bosentan with Palbociclib?
MediHelp rates the interaction as moderate. Bosentan and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may reduce palbociclib exposure. This could lower antitumor efficacy.
How serious is the interaction between Bosentan and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response; consider an alternative to bosentan where feasible. Avoid strong inducers, and moderate inducers need closer attention.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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