Drug interactions
Bosentan + Ruxolitinib
Severity: Minor
Bosentan and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may modestly reduce ruxolitinib exposure. The clinical effect is usually small because the active metabolites partly compensate.
What this interaction means in plain words
Bosentan and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Ruxolitinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing ruxolitinib metabolism.
What to do
No empirical dose change is usually needed. Monitor blood counts and clinical response to ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ruxolitinib
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ruxolitinib?
MediHelp rates the interaction as minor. Bosentan and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate CYP3A4 inducer and may modestly reduce ruxolitinib exposure. The clinical effect is usually small because the active metabolites partly compensate.
How serious is the interaction between Bosentan and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is usually needed. Monitor blood counts and clinical response to ruxolitinib.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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