Drug interactions
Bosentan + Stiripentol
Severity: Moderate
Bosentan and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce stiripentol concentrations, with potential loss of seizure control. The effect is likely modest because bosentan is a moderate inducer.
What this interaction means in plain words
Bosentan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Stiripentol belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing stiripentol metabolism.
What to do
Monitor seizure frequency and consider stiripentol dose adjustment if control worsens. Check stiripentol levels where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Bosentan with Stiripentol?
MediHelp rates the interaction as moderate. Bosentan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce stiripentol concentrations, with potential loss of seizure control. The effect is likely modest because bosentan is a moderate inducer.
How serious is the interaction between Bosentan and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and consider stiripentol dose adjustment if control worsens. Check stiripentol levels where available.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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