Drug interactions
Bosentan + Temsirolimus
Severity: Moderate
Bosentan and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, and bosentan, a CYP3A4 inducer, may lower their exposure. This could reduce antitumour effect.
What this interaction means in plain words
Bosentan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing metabolism of temsirolimus and sirolimus.
What to do
Monitor for reduced response and avoid combination if possible. If needed, consider temsirolimus dose adjustment per labeling for CYP3A4 inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Temsirolimus?
MediHelp rates the interaction as moderate. Bosentan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, and bosentan, a CYP3A4 inducer, may lower their exposure. This could reduce antitumour effect.
How serious is the interaction between Bosentan and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and avoid combination if possible. If needed, consider temsirolimus dose adjustment per labeling for CYP3A4 inducers.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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