Drug interactions
Bosentan + Upadacitinib
Severity: Moderate
Bosentan and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Upadacitinib is metabolized by CYP3A4, and inducers can reduce its exposure. Bosentan is a moderate inducer, so efficacy may decrease; labeling advises avoiding strong inducers.
What this interaction means in plain words
Bosentan and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Bosentan induces CYP3A4, increasing upadacitinib clearance.
What to do
Monitor for loss of disease control, and consider alternatives if response declines. Avoid strong CYP3A4 inducers altogether.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Bosentan with Upadacitinib?
MediHelp rates the interaction as moderate. Bosentan and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Upadacitinib is metabolized by CYP3A4, and inducers can reduce its exposure. Bosentan is a moderate inducer, so efficacy may decrease; labeling advises avoiding strong inducers.
How serious is the interaction between Bosentan and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of disease control, and consider alternatives if response declines. Avoid strong CYP3A4 inducers altogether.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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