Drug interactions
Enzalutamide + Velpatasvir
Severity: Major
Enzalutamide and Velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir is cleared by CYP3A4, CYP2C8 and CYP2B6, and enzalutamide can induce these enzymes. Lower velpatasvir levels may result in hepatitis C treatment failure.
What this interaction means in plain words
Enzalutamide and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Velpatasvir belongs to Anti Virals.
Why it happens
Enzalutamide induces CYP3A4, CYP2C8, CYP2B6 and P-gp, reducing velpatasvir exposure.
What to do
Do not coadminister; postpone HCV therapy or choose an alternative regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Enzalutamide with Velpatasvir?
MediHelp rates the interaction as major. Enzalutamide and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir is cleared by CYP3A4, CYP2C8 and CYP2B6, and enzalutamide can induce these enzymes. Lower velpatasvir levels may result in hepatitis C treatment failure.
How serious is the interaction between Enzalutamide and Velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; postpone HCV therapy or choose an alternative regimen.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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