Drug interactions
Bosentan + Vortioxetine
Severity: Moderate
Bosentan and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 and CYP2C9 inducer and may lower vortioxetine concentrations. This could reduce antidepressant efficacy, although the induction is weaker than that of strong inducers such as rifampicin.
What this interaction means in plain words
Bosentan and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Vortioxetine belongs to Central Nervous System.
Why it happens
Bosentan induces hepatic CYP enzymes, increasing vortioxetine metabolism.
What to do
Monitor for reduced antidepressant response and consider increasing the vortioxetine dose, within the labeled maximum, if needed. Reduce the dose back if bosentan is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Vortioxetine?
MediHelp rates the interaction as moderate. Bosentan and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 and CYP2C9 inducer and may lower vortioxetine concentrations. This could reduce antidepressant efficacy, although the induction is weaker than that of strong inducers such as rifampicin.
How serious is the interaction between Bosentan and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and consider increasing the vortioxetine dose, within the labeled maximum, if needed. Reduce the dose back if bosentan is withdrawn.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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