Drug interactions
Bosentan + Zonisamide
Severity: Minor
Bosentan and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a modest CYP3A4 inducer and may lower zonisamide concentrations, since zonisamide is partly cleared by CYP3A4. The clinical effect is probably small but could reduce seizure control.
What this interaction means in plain words
Bosentan and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Zonisamide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by bosentan, increasing zonisamide metabolism.
What to do
Monitor seizure control after bosentan is started or stopped. Adjust the zonisamide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Zonisamide?
MediHelp rates the interaction as minor. Bosentan and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a modest CYP3A4 inducer and may lower zonisamide concentrations, since zonisamide is partly cleared by CYP3A4. The clinical effect is probably small but could reduce seizure control.
How serious is the interaction between Bosentan and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control after bosentan is started or stopped. Adjust the zonisamide dose if needed.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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