Drug interactions
Bosutinib + Digoxin
Severity: Moderate
Bosutinib and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein in vitro and may raise digoxin exposure. Because digoxin has a narrow therapeutic index, increased levels could cause toxicity.
What this interaction means in plain words
Bosutinib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Digoxin belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition decreases digoxin intestinal and renal efflux.
What to do
Monitor digoxin levels and signs of toxicity when bosutinib is started or stopped; adjust digoxin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Digoxin?
MediHelp rates the interaction as moderate. Bosutinib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein in vitro and may raise digoxin exposure. Because digoxin has a narrow therapeutic index, increased levels could cause toxicity.
How serious is the interaction between Bosutinib and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and signs of toxicity when bosutinib is started or stopped; adjust digoxin dose accordingly.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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