Drug interactions
Bosutinib + Estradiol
Severity: Minor
Bosutinib and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein in vitro, and this could in theory raise estradiol exposure. No meaningful clinical effect has been well documented.
What this interaction means in plain words
Bosutinib and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Estradiol belongs to Endocrine.
Why it happens
Possible inhibition of P-glycoprotein efflux of estradiol by bosutinib; the clinical significance is not established.
What to do
No routine adjustment is needed. Watch for estrogenic adverse effects such as breast tenderness or fluid retention and reduce the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Estradiol?
MediHelp rates the interaction as minor. Bosutinib and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosutinib inhibits P-glycoprotein in vitro, and this could in theory raise estradiol exposure. No meaningful clinical effect has been well documented.
How serious is the interaction between Bosutinib and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for estrogenic adverse effects such as breast tenderness or fluid retention and reduce the estradiol dose if they occur.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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