Drug interactions
Bosutinib + Pravastatin
Severity: Minor
Bosutinib and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-gp and may slightly increase pravastatin exposure. Clinical consequences are probably minor but muscle toxicity is possible.
What this interaction means in plain words
Bosutinib and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Pravastatin belongs to Cardiovascular.
Why it happens
Bosutinib inhibits P-glycoprotein, increasing pravastatin absorption.
What to do
Monitor for muscle pain or weakness and reduce the pravastatin dose if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Pravastatin?
MediHelp rates the interaction as minor. Bosutinib and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosutinib inhibits P-gp and may slightly increase pravastatin exposure. Clinical consequences are probably minor but muscle toxicity is possible.
How serious is the interaction between Bosutinib and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and reduce the pravastatin dose if symptoms develop.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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