Drug interactions
Bosutinib + Tiotropium-olodaterol
Severity: Moderate
Bosutinib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib can prolong the QT interval, and beta2-agonists may add to cardiac excitability and lower potassium. The combination may increase the risk of ventricular arrhythmias in susceptible patients. Systemic olodaterol exposure from inhalation is low.
What this interaction means in plain words
Bosutinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-mediated hypokalemia and cardiac stimulation.
What to do
Check ECG and correct potassium and magnesium before and during therapy in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Bosutinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib can prolong the QT interval, and beta2-agonists may add to cardiac excitability and lower potassium. The combination may increase the risk of ventricular arrhythmias in susceptible patients. Systemic olodaterol exposure from inhalation is low.
How serious is the interaction between Bosutinib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during therapy in patients with additional QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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