Drug interactions
Bremelanotide + Midazolam
Severity: Minor
Bremelanotide and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide may slow gastric emptying and thereby delay or reduce the absorption of oral drugs. Oral midazolam may therefore have a slower onset or lesser effect, whereas parenteral midazolam is not expected to be affected.
What this interaction means in plain words
Bremelanotide and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bremelanotide belongs to Genitourinary; Midazolam belongs to Central Nervous System.
Why it happens
Delayed gastric emptying from bremelanotide may reduce the rate and extent of oral midazolam absorption.
What to do
For oral midazolam where reliable effect is needed, titrate to response or use a parenteral route. No change is needed for IV or IM midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporin Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Frequently asked questions
Can I take Bremelanotide with Midazolam?
MediHelp rates the interaction as minor. Bremelanotide and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bremelanotide may slow gastric emptying and thereby delay or reduce the absorption of oral drugs. Oral midazolam may therefore have a slower onset or lesser effect, whereas parenteral midazolam is not expected to be affected.
How serious is the interaction between Bremelanotide and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For oral midazolam where reliable effect is needed, titrate to response or use a parenteral route. No change is needed for IV or IM midazolam.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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