Drug interactions
Bremelanotide + Sirolimus
Severity: Minor
Bremelanotide and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide slows gastric emptying and may reduce the rate and extent of absorption of oral drugs. For a narrow-therapeutic-index drug like sirolimus, the effect is uncertain but could lower exposure.
What this interaction means in plain words
Bremelanotide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bremelanotide belongs to Genitourinary; Sirolimus belongs to Miscellaneous.
Why it happens
Delayed gastric emptying may reduce oral absorption of sirolimus.
What to do
Monitor sirolimus trough levels if bremelanotide is used regularly. Doses are intermittent, so routine adjustment is rarely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporin Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Frequently asked questions
Can I take Bremelanotide with Sirolimus?
MediHelp rates the interaction as minor. Bremelanotide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bremelanotide slows gastric emptying and may reduce the rate and extent of absorption of oral drugs. For a narrow-therapeutic-index drug like sirolimus, the effect is uncertain but could lower exposure.
How serious is the interaction between Bremelanotide and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels if bremelanotide is used regularly. Doses are intermittent, so routine adjustment is rarely needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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