Drug interactions
Brentuximab + Fedratinib
Severity: Moderate
Brentuximab and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may raise exposure to monomethyl auristatin E (MMAE), the cytotoxic payload released from brentuximab vedotin. This could increase the risk of neutropenia and peripheral neuropathy, though the effect of a moderate inhibitor has not been well characterized.
What this interaction means in plain words
Brentuximab and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibition of CYP3A4 may reduce clearance of free MMAE.
What to do
Monitor blood counts and watch for emerging peripheral neuropathy and infection. Consider dose adjustment of brentuximab if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brentuximab and Fedratinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Brentuximab with Fedratinib?
MediHelp rates the interaction as moderate. Brentuximab and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may raise exposure to monomethyl auristatin E (MMAE), the cytotoxic payload released from brentuximab vedotin. This could increase the risk of neutropenia and peripheral neuropathy, though the effect of a moderate inhibitor has not been well characterized.
How serious is the interaction between Brentuximab and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for emerging peripheral neuropathy and infection. Consider dose adjustment of brentuximab if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
