Drug interactions
Brentuximab + Lopinavir
Severity: Moderate
Brentuximab and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, which is given with ritonavir, inhibits CYP3A4 and may increase MMAE exposure after brentuximab vedotin. Neutropenia and peripheral neuropathy may be more likely.
What this interaction means in plain words
Brentuximab and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Lopinavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted CYP3A4 inhibition reduces MMAE clearance.
What to do
Monitor complete blood counts and neuropathy symptoms. Delay or reduce brentuximab for significant toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Brentuximab with Lopinavir?
MediHelp rates the interaction as moderate. Brentuximab and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, which is given with ritonavir, inhibits CYP3A4 and may increase MMAE exposure after brentuximab vedotin. Neutropenia and peripheral neuropathy may be more likely.
How serious is the interaction between Brentuximab and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and neuropathy symptoms. Delay or reduce brentuximab for significant toxicity.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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