Drug interactions
Brexpiprazole + Bupropion-naltrexone
Severity: Moderate
Brexpiprazole and Bupropion-naltrexone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and can raise brexpiprazole concentrations, increasing the risk of adverse effects such as akathisia, sedation and metabolic effects. The effect is larger if a CYP3A4 inhibitor is also present.
What this interaction means in plain words
Brexpiprazole and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Bupropion-naltrexone belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6-mediated brexpiprazole metabolism by bupropion and its metabolites.
What to do
Reduce the brexpiprazole dose to about half when used with bupropion, and further if a CYP3A4 inhibitor is also given. Monitor for akathisia and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Bupropion-naltrexone?
MediHelp rates the interaction as moderate. Brexpiprazole and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion is a strong CYP2D6 inhibitor and can raise brexpiprazole concentrations, increasing the risk of adverse effects such as akathisia, sedation and metabolic effects. The effect is larger if a CYP3A4 inhibitor is also present.
How serious is the interaction between Brexpiprazole and Bupropion-naltrexone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the brexpiprazole dose to about half when used with bupropion, and further if a CYP3A4 inhibitor is also given. Monitor for akathisia and other adverse effects.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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