Drug interactions
Brexpiprazole + Bupropion
Severity: Moderate
Brexpiprazole and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and can substantially increase brexpiprazole exposure. This raises the risk of dose-related adverse effects such as akathisia, sedation and metabolic effects.
What this interaction means in plain words
Brexpiprazole and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Bupropion belongs to Central Nervous System.
Why it happens
Bupropion and its metabolites inhibit CYP2D6, which is a main route of brexpiprazole metabolism.
What to do
Labeling advises reducing the brexpiprazole dose to about half with strong CYP2D6 inhibitors (except in MDD adjunct use, where dosing already accounts for it). Monitor for adverse effects and adjust the dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Bupropion?
MediHelp rates the interaction as moderate. Brexpiprazole and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion is a strong CYP2D6 inhibitor and can substantially increase brexpiprazole exposure. This raises the risk of dose-related adverse effects such as akathisia, sedation and metabolic effects.
How serious is the interaction between Brexpiprazole and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling advises reducing the brexpiprazole dose to about half with strong CYP2D6 inhibitors (except in MDD adjunct use, where dosing already accounts for it). Monitor for adverse effects and adjust the dose to response.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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