Drug interactions
Brexpiprazole + Cinacalcet
Severity: Moderate
Brexpiprazole and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and can raise brexpiprazole levels. Higher exposure may increase adverse effects such as sedation, akathisia, and orthostatic hypotension.
What this interaction means in plain words
Brexpiprazole and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Cinacalcet belongs to Miscellaneous.
Why it happens
Cinacalcet inhibits CYP2D6, reducing brexpiprazole clearance.
What to do
Reduce the brexpiprazole dose to about half the usual dose during cinacalcet use, following labeling for strong CYP2D6 inhibitors. Monitor for adverse effects and restore the dose after cinacalcet is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Brexpiprazole with Cinacalcet?
MediHelp rates the interaction as moderate. Brexpiprazole and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a strong CYP2D6 inhibitor and can raise brexpiprazole levels. Higher exposure may increase adverse effects such as sedation, akathisia, and orthostatic hypotension.
How serious is the interaction between Brexpiprazole and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the brexpiprazole dose to about half the usual dose during cinacalcet use, following labeling for strong CYP2D6 inhibitors. Monitor for adverse effects and restore the dose after cinacalcet is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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