Drug interactions
Brexpiprazole + Clobazam
Severity: Moderate
Brexpiprazole and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP2D6 inhibitor and may modestly raise brexpiprazole exposure, which matters more if a CYP3A4 inhibitor is also given or in CYP2D6 poor metabolizers. Both drugs also cause sedation, so combined use can increase drowsiness and impairment.
What this interaction means in plain words
Brexpiprazole and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Mild CYP2D6 inhibition by clobazam raising brexpiprazole levels, plus additive CNS depression via GABA-A and antihistaminic effects.
What to do
Monitor for sedation, orthostasis and brexpiprazole adverse effects and reduce the dose if a CYP3A4 inhibitor is also present, per labeling. Advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Brexpiprazole with Clobazam?
MediHelp rates the interaction as moderate. Brexpiprazole and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP2D6 inhibitor and may modestly raise brexpiprazole exposure, which matters more if a CYP3A4 inhibitor is also given or in CYP2D6 poor metabolizers. Both drugs also cause sedation, so combined use can increase drowsiness and impairment.
How serious is the interaction between Brexpiprazole and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and brexpiprazole adverse effects and reduce the dose if a CYP3A4 inhibitor is also present, per labeling. Advise caution with driving.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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