Drug interactions
Brexpiprazole + Clomipramine
Severity: Moderate
Brexpiprazole and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has CYP2D6 inhibiting properties and may raise brexpiprazole exposure, since brexpiprazole is cleared by CYP2D6 and CYP3A4. Both drugs also cause sedation, so drowsiness and psychomotor impairment may be more pronounced.
What this interaction means in plain words
Brexpiprazole and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 by clomipramine reduces brexpiprazole clearance, together with additive CNS depressant effects.
What to do
Monitor for brexpiprazole adverse effects such as akathisia, sedation and orthostasis, and reduce its dose if a CYP2D6 inhibitor is combined with a CYP3A4 inhibitor. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Clomipramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has CYP2D6 inhibiting properties and may raise brexpiprazole exposure, since brexpiprazole is cleared by CYP2D6 and CYP3A4. Both drugs also cause sedation, so drowsiness and psychomotor impairment may be more pronounced.
How serious is the interaction between Brexpiprazole and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects such as akathisia, sedation and orthostasis, and reduce its dose if a CYP2D6 inhibitor is combined with a CYP3A4 inhibitor. Counsel patients about driving and operating machinery.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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