Drug interactions
Brexpiprazole + Clorazepate
Severity: Moderate
Brexpiprazole and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so combining them may increase drowsiness, dizziness and impaired alertness. The risk is greater in older adults and at higher doses.
What this interaction means in plain words
Brexpiprazole and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and the sedating antihistaminic and antiadrenergic effects of brexpiprazole.
What to do
Monitor for oversedation and orthostatic symptoms, especially during titration. Give counselling on driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Clorazepate?
MediHelp rates the interaction as moderate. Brexpiprazole and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so combining them may increase drowsiness, dizziness and impaired alertness. The risk is greater in older adults and at higher doses.
How serious is the interaction between Brexpiprazole and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic symptoms, especially during titration. Give counselling on driving and fall precautions.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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