Drug interactions
Brexpiprazole + Crizotinib
Severity: Moderate
Brexpiprazole and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may modestly increase brexpiprazole exposure. The risk is greater if a CYP2D6 inhibitor is also present or the patient is a CYP2D6 poor metabolizer.
What this interaction means in plain words
Brexpiprazole and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism of brexpiprazole.
What to do
Monitor for sedation, akathisia, and hypotension. Reduce brexpiprazole to a quarter of the usual dose if a CYP2D6 inhibitor is also given, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Crizotinib?
MediHelp rates the interaction as moderate. Brexpiprazole and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may modestly increase brexpiprazole exposure. The risk is greater if a CYP2D6 inhibitor is also present or the patient is a CYP2D6 poor metabolizer.
How serious is the interaction between Brexpiprazole and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia, and hypotension. Reduce brexpiprazole to a quarter of the usual dose if a CYP2D6 inhibitor is also given, per labeling.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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