Drug interactions
Brexpiprazole + Difelikefalin
Severity: Moderate
Brexpiprazole and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and brexpiprazole is also sedating, so drowsiness may be increased. The clinical effect is generally modest but may raise fall risk in dialysis patients.
What this interaction means in plain words
Brexpiprazole and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS-depressant effects; difelikefalin is a peripherally restricted kappa-opioid agonist with some sedative effects.
What to do
Monitor for excess drowsiness, dizziness and falls, particularly after dialysis. Reduce doses or reassess therapy if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Brexpiprazole with Difelikefalin?
MediHelp rates the interaction as moderate. Brexpiprazole and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and brexpiprazole is also sedating, so drowsiness may be increased. The clinical effect is generally modest but may raise fall risk in dialysis patients.
How serious is the interaction between Brexpiprazole and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness, dizziness and falls, particularly after dialysis. Reduce doses or reassess therapy if sedation becomes problematic.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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