Drug interactions
Brexpiprazole + Dronedarone
Severity: Moderate
Brexpiprazole and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits both CYP3A4 (moderately) and CYP2D6, the two enzymes that clear brexpiprazole. Combined inhibition can substantially increase brexpiprazole exposure and the risk of adverse effects such as sedation, akathisia and orthostatic hypotension.
What this interaction means in plain words
Brexpiprazole and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4 and CYP2D6, reducing brexpiprazole clearance.
What to do
Reduce the brexpiprazole dose to about one quarter of the usual dose per labeling when combined with dual CYP2D6 and CYP3A4 inhibition. Return to the usual dose after dronedarone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Dronedarone?
MediHelp rates the interaction as moderate. Brexpiprazole and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits both CYP3A4 (moderately) and CYP2D6, the two enzymes that clear brexpiprazole. Combined inhibition can substantially increase brexpiprazole exposure and the risk of adverse effects such as sedation, akathisia and orthostatic hypotension.
How serious is the interaction between Brexpiprazole and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the brexpiprazole dose to about one quarter of the usual dose per labeling when combined with dual CYP2D6 and CYP3A4 inhibition. Return to the usual dose after dronedarone is stopped.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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