Drug interactions
Brexpiprazole + Eliglustat
Severity: Moderate
Brexpiprazole and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6 and may raise brexpiprazole exposure. The effect is greater if CYP3A4 inhibitors are also taken.
What this interaction means in plain words
Brexpiprazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits CYP2D6, reducing brexpiprazole metabolism.
What to do
Monitor for brexpiprazole adverse effects. Reduce the dose to a quarter if a CYP3A4 inhibitor is also in use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Eliglustat?
MediHelp rates the interaction as moderate. Brexpiprazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6 and may raise brexpiprazole exposure. The effect is greater if CYP3A4 inhibitors are also taken.
How serious is the interaction between Brexpiprazole and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects. Reduce the dose to a quarter if a CYP3A4 inhibitor is also in use.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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