Drug interactions
Brexpiprazole + Etravirine
Severity: Moderate
Brexpiprazole and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer that can lower brexpiprazole concentrations and reduce its efficacy. Its induction is weaker than that of rifampin, so the effect is likely smaller.
What this interaction means in plain words
Brexpiprazole and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by etravirine increases brexpiprazole metabolism.
What to do
Monitor for loss of psychiatric symptom control and increase the brexpiprazole dose based on clinical response. Reassess the dose if etravirine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Brexpiprazole with Etravirine?
MediHelp rates the interaction as moderate. Brexpiprazole and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer that can lower brexpiprazole concentrations and reduce its efficacy. Its induction is weaker than that of rifampin, so the effect is likely smaller.
How serious is the interaction between Brexpiprazole and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control and increase the brexpiprazole dose based on clinical response. Reassess the dose if etravirine is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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