Drug interactions
Brexpiprazole + Fosaprepitant
Severity: Minor
Brexpiprazole and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, and with a single dose the effect on brexpiprazole is probably small and short-lived. The risk matters mainly if a CYP2D6 inhibitor is also present.
What this interaction means in plain words
Brexpiprazole and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Weak to moderate, transient CYP3A4 inhibition by aprepitant reduces brexpiprazole clearance.
What to do
No routine adjustment is needed for a single dose; monitor for sedation and akathisia. Reduce the brexpiprazole dose if a CYP2D6 inhibitor is also being taken.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Brexpiprazole with Fosaprepitant?
MediHelp rates the interaction as minor. Brexpiprazole and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, and with a single dose the effect on brexpiprazole is probably small and short-lived. The risk matters mainly if a CYP2D6 inhibitor is also present.
How serious is the interaction between Brexpiprazole and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for a single dose; monitor for sedation and akathisia. Reduce the brexpiprazole dose if a CYP2D6 inhibitor is also being taken.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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