Drug interactions
Brexpiprazole + Haloperidol
Severity: Moderate
Brexpiprazole and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 and is a CYP3A4 substrate and weak inhibitor, so it may raise brexpiprazole exposure. Both are antipsychotics, so additive sedation, QT effects and extrapyramidal or neuroleptic malignant syndrome risk can occur.
What this interaction means in plain words
Brexpiprazole and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
CYP2D6 and CYP3A4 inhibition reduces brexpiprazole clearance, together with additive dopamine blockade and CNS depression.
What to do
Avoid combining antipsychotics where possible; if combined, monitor for adverse effects such as sedation and extrapyramidal symptoms. Reduce the brexpiprazole dose if exposure is increased by multiple inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Haloperidol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Haloperidol?
MediHelp rates the interaction as moderate. Brexpiprazole and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol inhibits CYP2D6 and is a CYP3A4 substrate and weak inhibitor, so it may raise brexpiprazole exposure. Both are antipsychotics, so additive sedation, QT effects and extrapyramidal or neuroleptic malignant syndrome risk can occur.
How serious is the interaction between Brexpiprazole and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining antipsychotics where possible; if combined, monitor for adverse effects such as sedation and extrapyramidal symptoms. Reduce the brexpiprazole dose if exposure is increased by multiple inhibitors.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
