Drug interactions
Brexpiprazole + Hydroxyzine
Severity: Moderate
Brexpiprazole and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine and can prolong the QT interval, while brexpiprazole causes somnolence. Together they may increase drowsiness and possibly add to QT concerns.
What this interaction means in plain words
Brexpiprazole and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 antagonism and antipsychotic effects, with possible additive QT effects.
What to do
Counsel on sedation and avoid driving if impaired. Consider an ECG and electrolyte check in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Brexpiprazole with Hydroxyzine?
MediHelp rates the interaction as moderate. Brexpiprazole and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine and can prolong the QT interval, while brexpiprazole causes somnolence. Together they may increase drowsiness and possibly add to QT concerns.
How serious is the interaction between Brexpiprazole and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving if impaired. Consider an ECG and electrolyte check in patients with QT risk factors.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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