Drug interactions
Brexpiprazole + Iloperidone
Severity: Moderate
Brexpiprazole and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics, so combining them adds sedation, orthostatic hypotension and QT-prolonging potential, with no established benefit over monotherapy. Iloperidone also inhibits CYP2D6 and CYP3A4 weakly, which may modestly raise brexpiprazole exposure.
What this interaction means in plain words
Brexpiprazole and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects (sedation, hypotension, QT) plus weak CYP2D6/3A4 inhibition by iloperidone.
What to do
Avoid routine antipsychotic polypharmacy; if used, monitor ECG, blood pressure and sedation. Adjust brexpiprazole dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Brexpiprazole with Iloperidone?
MediHelp rates the interaction as moderate. Brexpiprazole and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics, so combining them adds sedation, orthostatic hypotension and QT-prolonging potential, with no established benefit over monotherapy. Iloperidone also inhibits CYP2D6 and CYP3A4 weakly, which may modestly raise brexpiprazole exposure.
How serious is the interaction between Brexpiprazole and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine antipsychotic polypharmacy; if used, monitor ECG, blood pressure and sedation. Adjust brexpiprazole dose if adverse effects emerge.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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